A Chlorinated Diketopiperazine Antibiotic Targets Mycobacterium Tuberculosis DNA Gyrase
Libang Liang, Jeffery E. Quigley, Monique E. Theriault, Akira Iinishi, Rachel Bargabos, Madeleine Morrissette, Megan Ghiglieri, Tom Curtis, Rachel Corsetti, Sangkeun Son, Bishwarup Sarkar, Kim Lewis
The paper identifies speirobactin, a novel antibiotic from Photorhabdus, which targets DNA gyrase in Mycobacterium tuberculosis and clusters with fluoroquinolones in transcriptome analysis.
bioRxiv · Mar 10, 2025 · PreprintCell Biology