KIF5A binds RNA to orchestrate synaptic mRNA localization and stress granules in ALS
Phuong Le, Neeraj K. Lal, Shuhao Xu, Sara Mumford, Megan Huang, Dong Yang, Orel Mizrahi, Benjamin Hoover, Brian Yee, Mei Yuan, Katherine Rothamel, Hsuan-Lin Her, Steven M. Blue, Neil A. Shneider, Gene Wei-Ming Yeo
This study shows KIF5A binds RNA to regulate synaptic mRNA localization and stress granules, with ALS mutations disrupting synaptic homeostasis.
bioRxiv · Oct 31, 2025 · PreprintNeuroscience