Orel Mizrahi

This study shows KIF5A binds RNA to regulate synaptic mRNA localization and stress granules, with ALS mutations disrupting synaptic homeostasis.

This study identifies mitochondrial-derived double-stranded RNA as a source of RNA stress in aged neurons, which activates the ISR through PKR and contributes to neurodegeneration.

The paper identifies PUF60's role in cancer progression by combining CRISPR screens and RNA-omics, showing its splicing activity supports TNBC proliferation and is a potential therapeutic target.

This study shows LARP6 regulates fibrogenic gene translation in liver fibrosis by interacting with collagen mRNAs and reducing fibrosis in human HSCs.

The paper constructs an RNA-aware RBP-centric PPI map across the mRNA life-cycle, revealing 20,359 novel interactions and showing 73% are RNA-dependent.

The paper examines dynamic changes in tRNA modifications and abundance during T-cell activation, finding reduced wybutosine and ms2t6A modifications that may increase ribosomal frameshifting and facilitate HIV infection.

The paper investigates functional compensation among Ythdf m6A readers in mouse gametogenesis and embryonic stem cells, revealing dosage-dependent redundancy and distinct roles.