Attenuation of Atherosclerosis with PAR4 Deficiency: Differential Platelet Outcomes in apoE-/- vs. Ldlr-/- Mice
Caris A. Wadding-Lee, Megan Jay, Shannon M. Shearer, Tyler W. Benson, Anthony R. Spuzzillo, Deborah A. Howatt, Joel C. Thompson, Benjamin E. Tourdot, Alan Daugherty, Nigel Mackman, Albert Phillip Owens
This study shows that PAR4 deficiency reduces atherosclerosis in Ldlr-/- mice, with effects mediated by hematopoietic cells, particularly platelets, and highlights differences in platelet reactivity between apoE-/- and Ldlr-/- models.
Arteriosclerosis Thrombosis and Vascular Biology · Apr 24, 2025Peer-reviewedPathology