Author

Nigel Mackman

University of North Carolina at Chapel HillORCID 0000-0002-9170-7700Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

Alan DaughertyiD· 2 shared Albert Phillip OwensiD· 2 shared Anthony R. SpuzzilloiD· 2 shared Deborah A. HowattiD· 2 shared Tyler W. BensoniD· 2 shared Wolfgang BergmeieriD· 2 shared Benjamin E. TourdotiD· 1 shared Bernhard NieswandtiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPathology

Alan DaughertyORCID

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3 papers

Recent·Most cited

Lack of canonical PAR4 activation is associated with reduced arterial and venous thrombosis in mice.

Robert Hugh Lee, Jenna R. Severa, David S. Paul, Woosuk S. Hur, Swati Sharma, Dale O. Cowley, Matthew J. Flick, Wolfgang Bergmeier, Nigel Mackman, Timothy J. Stalker, Silvio Antoniak

This study creates a mouse model with a thrombin-insensitive PAR4 receptor, showing reduced thrombosis but normal responses to PAR4 agonists.

bioRxiv · Jul 23, 2026 · PreprintPathology

Attenuation of Atherosclerosis with PAR4 Deficiency: Differential Platelet Outcomes in apoE-/- vs. Ldlr-/- Mice

Caris A. Wadding-Lee, Megan Jay, Shannon M. Shearer, Tyler W. Benson, Anthony R. Spuzzillo, Deborah A. Howatt, Joel C. Thompson, Benjamin E. Tourdot, Alan Daugherty, Nigel Mackman, Albert Phillip Owens

This study shows that PAR4 deficiency reduces atherosclerosis in Ldlr-/- mice, with effects mediated by hematopoietic cells, particularly platelets, and highlights differences in platelet reactivity between apoE-/- and Ldlr-/- models.

Arteriosclerosis Thrombosis and Vascular Biology · Apr 24, 2025Peer-reviewedPathology

Platelets are Protective in Early Abdominal Aortic Aneurysm Formation

Hannah Russell, Anthony R. Spuzzillo, Tyler W. Benson, James Jaworski, Marc Clément, Yacine Boulaftali, Keith Louis Saum, Kelsey A. Conrad, Deborah A. Howatt, James P. Luyendyk, Scott J. Cameron, Bernhard Nieswandt, Steven R. Steinhubl, Alan Daugherty, Wolfgang Bergmeier, , Albert Phillip Owens

This study shows that platelet inhibition increases rupture risk in early abdominal aortic aneurysm models in mice.

bioRxiv · Oct 29, 2024 · PreprintPathology