IL-1Ra and CCL5, but not IL-10, are promising targets for treating SMA astrocyte-driven pathology
Reilly L. Allison, Cecelia C Mangione, Mya Suneja, Jessica E. Gawrys, Brendan M. Melvin, Natalya Belous, Megan LaCroix, Matthew M. Harmelink, Barrington G. Burnett, Allison D. Ebert
This study identifies IL-1ra and CCL5 as potential therapeutic targets for SMA by showing they reduce astrocyte-driven inflammation and improve disease outcomes in vitro and in mice.
Molecular Therapy · Dec 12, 2024Peer-reviewedNeuroscience