Author

Reilly L. Allison

Medical College of WisconsinORCID 0000-0002-0074-4099Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 1

Frequent Co-Authors

Allison D. EbertiD· 5 shared Barrington G. BurnettiD· 2 shared Amanda M. BrandowiD· 1 shared Angela MathisoniD· 1 shared Anthony J. BurandiD· 1 shared Brendan M. Melvin· 1 shared Cecelia C Mangione· 1 shared Cheryl L. StuckyiD· 1 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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5 shared papersNeuroscience

Allison D. EbertORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

IL-1Ra and CCL5, but not IL-10, are promising targets for treating SMA astrocyte-driven pathology

Reilly L. Allison, Cecelia C Mangione, Mya Suneja, Jessica E. Gawrys, Brendan M. Melvin, Natalya Belous, Megan LaCroix, Matthew M. Harmelink, Barrington G. Burnett, Allison D. Ebert

This study identifies IL-1ra and CCL5 as potential therapeutic targets for SMA by showing they reduce astrocyte-driven inflammation and improve disease outcomes in vitro and in mice.

Molecular Therapy · Dec 12, 2024Peer-reviewedNeuroscience

ALS iPSC-derived microglia and motor neurons respond to astrocyte-targeted IL-10 and CCL2 modulation

Reilly L. Allison, Allison D. Ebert

The paper tests astrocyte-targeted IL-10 and CCL2 modulation in ALS iPSC models, finding reduced neuroinflammation and altered microglia/motor neuron responses in co-cultures.

Human Molecular Genetics · Dec 20, 2023Peer-reviewedNeuroscience

Sickle cell disease patient plasma sensitizes iPSC-derived sensory neurons from sickle cell disease patients

Reilly L. Allison, Anthony J. Burand, Damaris Nieves Torres, Amanda M. Brandow, Cheryl L. Stucky, Allison D. Ebert

The paper uses SCD patient-derived iPSCs to study sensory neuron function and identifies plasma factors that sensitize neurons to pain stimuli.

Blood · Nov 15, 2022Peer-reviewedNeuroscience

Viral mediated knockdown of GATA6 in SMA iPSC-derived astrocytes prevents motor neuron loss and microglial activation

Reilly L. Allison, Emily Welby, Guzal Khayrullina, Barrington G. Burnett, Allison D. Ebert

Glia · Jan 28, 2022Peer-reviewedNeuroscience

Microglia influence neurofilament deposition in ALS iPSC-derived motor neurons

Reilly L. Allison, Jacob W. Adelman, Jenica Abrudan, Raul A. Urrutia, Michael T. Zimmermann, Angela Mathison, Allison D. Ebert

This study investigates how microglia and astrocytes affect neurofilament accumulation in ALS iPSC-derived motor neurons, showing glial-secreted factors influence neurofilament pathology.

Genes · Jan 27, 2022Peer-reviewedNeuroscience