Author

Megan Muench

Thomas Jefferson University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Marco TiganoiD· 2 shared Alessandra MarescaiD· 1 shared Amandeep GirdhariD· 1 shared Angelo PolettiiD· 1 shared Chenxiao YuiD· 1 shared Davide TrottiiD· 1 shared Ivette Martorell SerraiD· 1 shared Jared L. SterneckertiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersNeuroscience

Marco TiganoORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

A Human Neuronal Cell Model of Endogenous TDP-43 A315T Reveals Altered Protein Dynamics and Disease-Relevant Cellular Dysfunction

M.E. Cicardi, Sara Antonini, Ivette Martorell Serra, Megan Muench, Nikolas G. Kinney, Amandeep Girdhar, Riccardo Cristofani, Angelo Poletti, Jared L. Sterneckert, V. Crippa, Matteo Bordi, Piera Pasinelli, Marco Tigano, Lin E. Guo, Davide Trotti

This study develops a human neuronal model with the TDP-43 A315T mutation to study ALS-related protein dysfunction and therapeutic responses.

bioRxiv · Sep 5, 2026 · PreprintNeuroscience

Mutations Causative of CPEO Differentially Engage Innate Immunity Sensors

Joshua Okletey, Megan Muench, Chenxiao Yu, Alessandra Maresca, Valério Carelli, Marco Tigano

This study shows that mutations in RNASEH1 and Twinkle trigger innate immune activation through different mitochondrial nucleic acid release mechanisms, leading to paracrine inflammation in CPEO.

bioRxiv · May 25, 2026 · PreprintCell Biology