Author

Joshua Okletey

Thomas Jefferson University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Chenxiao YuiD· 2 shared Marco TiganoiD· 2 shared Alessandra MarescaiD· 1 shared Emma Evens· 1 shared Marite Castromonte Albinagorta· 1 shared Megan Muench· 1 shared Sidney Tchiong· 1 shared Valério CarelliiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

Chenxiao YuORCID

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2 papers

Recent·Most cited

Nuclear DNA Damage Response Triggers Reorganization of Mitochondrial Nucleic Acids

Chenxiao Yu, Emma Evens, Sidney Tchiong, Marite Castromonte Albinagorta, Joshua Okletey, Marco Tigano

This study identifies mito-blobs as nuclear DNA damage-induced mitochondrial structures that concentrate immunogenic nucleic acids and influence inflammatory gene expression through autophagic clearance.

bioRxiv · May 25, 2026 · PreprintCell Biology

Mutations Causative of CPEO Differentially Engage Innate Immunity Sensors

Joshua Okletey, Megan Muench, Chenxiao Yu, Alessandra Maresca, Valério Carelli, Marco Tigano

This study shows that mutations in RNASEH1 and Twinkle trigger innate immune activation through different mitochondrial nucleic acid release mechanisms, leading to paracrine inflammation in CPEO.

bioRxiv · May 25, 2026 · PreprintCell Biology