Author

Alessandra Maresca

Istituto delle Scienze Neurologiche di BolognaORCID 0000-0002-8959-8832Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Marco TiganoiD· 2 shared Valério CarelliiD· 2 shared Alberto DaneseiD· 1 shared Alberto Pietro PastiiD· 1 shared Alessandro Rapone· 1 shared Anu SuomalaineniD· 1 shared Chenxiao YuiD· 1 shared Chiara La MorgiaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCell Biology

Marco TiganoORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Cell-free mtDNA drives pyroptosis and inflammation in m.3243A>G mitochondrial disease models

Monica Moresco, Alessandro Rapone, Concetta Valentina Tropeano, Mariantonietta Capristo, Giada Capirossi, Danara Ormanbekova, Claudio Fiorini, Alberto Pietro Pasti, Francesco Valle, Alberto Danese, Simone Patergnani, Leonardo Caporali, Chiara La Morgia, Anu Suomalainen, Paolo Pinton, , Alessandra Maresca

This study shows that the m.3243A>G mutation increases cell-free mtDNA release, triggering pyroptosis and inflammation in MELAS models.

bioRxiv · Jul 1, 2026 · PreprintCell Biology

Mutations Causative of CPEO Differentially Engage Innate Immunity Sensors

Joshua Okletey, Megan Muench, Chenxiao Yu, Alessandra Maresca, Valério Carelli, Marco Tigano

This study shows that mutations in RNASEH1 and Twinkle trigger innate immune activation through different mitochondrial nucleic acid release mechanisms, leading to paracrine inflammation in CPEO.

bioRxiv · May 25, 2026 · PreprintCell Biology