Conformational dynamics of the HIV-1 envelope glycoprotein from CRF01_AE is associated with susceptibility to antibody-dependent cellular cytotoxicity
Marco Aurelio Díaz-Salinas, Mehdi Benlarbi, Debashree Chatterjee, Manon Nayrac, Megane Robidas, Suteeraporn Pinyakorn, Nittaya Phanuphak, Carlo Sacdalan, Halima Medjahed, Jérémie Prévost, Lydie Trautmann, Marzena Pazgier, Andrés Finzi, James B. Munro
This paper shows HIV-1CRF01_AE Env frequently adopts an open conformation (State 2A) that is susceptible to ADCC, unlike clade A/B Envs which require anti-cluster A antibodies to reach this state.
Journal of Virology · Dec 9, 2025Peer-reviewedMicrobiology