Andrés Finzi

The paper links ALDH activity in monocytes to subclinical coronary atherosclerosis in HIV-1 treated individuals, independent of traditional risk factors.

This study shows that inhibiting REV-ERBβ increases HIV-1 reactivation in CD4+ T-cells but limits virion spread.

This study shows that HIV-1 infected cells with open Env conformations are vulnerable to ADCP mediated by PWH plasma, and that Nef and Vpu protect against this by preventing premature Env opening.

The paper introduces RF-PHATE, a supervised data visualization method that integrates expert knowledge to enhance interpretation of complex biological data.

This study identifies gene-environment interactions influencing immune response to SARS-CoV-2 in hospitalized patients using single-cell RNA-sequencing and eQTL analysis.

This paper shows HIV-1CRF01_AE Env frequently adopts an open conformation (State 2A) that is susceptible to ADCC, unlike clade A/B Envs which require anti-cluster A antibodies to reach this state.

This study shows that the CD4 mimetic CJF-III-288 enables anti-CoRBS antibodies to mediate ADCC by stabilizing an asymmetric open Env conformation.

This study shows that the HIV-1 envelope cytoplasmic tail downregulates CD4, protecting infected cells from ADCC by preventing Env conformational changes that expose epitopes recognized by CD4i antibodies and plasma from PLWH.

The paper shows CD4 downregulation precedes Env expression in HIV-1-infected cells, making them resistant to non-neutralizing antibody-mediated ADCC.

This paper combines three CD4-induced antibodies with a CD4-mimetic to achieve potent ADCC activity against HIV-1-infected cells.

This study shows metformin reduces HIV-1 virion release and increases antibody recognition of infected CD4+ T-cells by modulating BST2 and Bcl-2 expression in HIV-positive individuals on ART.

This study examines how temperature affects Spike-ACE2 interactions in Omicron subvariants and links these interactions to viral transmission efficiency.

This study identifies multiple molecular determinants of HIV-1 CRF01_AE resistance to temsavir, showing that resistance involves crosstalk between His375 and inner domain layers.

The paper tracks humoral responses against SARS-CoV-2 Spike in convalescent individuals over time, finding declines in IgG and IgM and neutralization capacity.