WRN helicase regulates mitophagy by resolving an intricate nexus of G-quadruplexes-R loops-ATG7 pre-mRNA maturation in cancer
Pooja Gupta, Mrityunjay Tyagi, Ananda Guha Majumdar, Ganesh Pai Bellare, Saikat Chakraborty, Shambhavi Mishra, Megha Tawate, Avik Chakraborty, Sujit K. Bhutia, Birija Sankar Patro
This paper identifies WRN's role in regulating mitophagy and autophagy in cancer by resolving G-quadruplexes and R-loops to enable proper ATG7 mRNA processing.
bioRxiv · Dec 14, 2025 · PreprintCell Biology