Cell BiologybioRxivPreprint
WRN helicase regulates mitophagy by resolving an intricate nexus of G-quadruplexes-R loops-ATG7 pre-mRNA maturation in cancer
Pooja Gupta, Mrityunjay Tyagi, Ananda Guha Majumdar…·Birija Sankar Patro
This paper identifies WRN's role in regulating mitophagy and autophagy in cancer by resolving G-quadruplexes and R-loops to enable proper ATG7 mRNA processing.
DOI 10.64898/2025.12.11.692796