Sphingosine synergizes with polymyxin antibiotics to kill Gram-negative bacteria
Jacob R. Mackinder, Meghan Quinlan, Matthew J. Wargo
This paper shows that sphingosine enhances the effectiveness of polymyxin antibiotics against Gram-negative bacteria like Pseudomonas aeruginosa and Klebsiella pneumoniae by reducing their minimum inhibitory concentrations.
bioRxiv · Jul 28, 2025 · PreprintMicrobiology