Author

Jacob R. Mackinder

University of Vermont

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:bacteria (other)· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Matthew J. WargoiD· 3 shared Kristin C. Schutz· 2 shared Pauline DiGianivittorioiD· 2 shared Aditya Patwardhan· 1 shared Eric A. KleiniD· 1 shared Lauren A. HinkeliD· 1 shared Meghan Quinlan· 1 shared Olivia EvansiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

Matthew J. WargoORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A genome-wide screen in Pseudomonas aeruginosa identifies genes impacting production of the hemolytic phospholipase C/sphingomyelinase, PlcH

Kristin C. Schutz, Olivia Evans, Jacob R. Mackinder, Pauline DiGianivittorio, Aditya Patwardhan, Matthew J. Wargo

This study identifies genes affecting PlcH production in Pseudomonas aeruginosa using a genome-wide transposon screen and confirms their roles through deletion mutants.

Journal of Bacteriology · Jul 27, 2026Peer-reviewedMicrobiology

Sphingosine synergizes with polymyxin antibiotics to kill Gram-negative bacteria

Jacob R. Mackinder, Meghan Quinlan, Matthew J. Wargo

This paper shows that sphingosine enhances the effectiveness of polymyxin antibiotics against Gram-negative bacteria like Pseudomonas aeruginosa and Klebsiella pneumoniae by reducing their minimum inhibitory concentrations.

bioRxiv · Jul 28, 2025 · PreprintMicrobiology

The Pseudomonas aeruginosa sphBC genes are important for growth in the presence of sphingosine by promoting sphingosine metabolism

Pauline DiGianivittorio, Lauren A. Hinkel, Jacob R. Mackinder, Kristin C. Schutz, Eric A. Klein, Matthew J. Wargo

This study shows that Pseudomonas aeruginosa uses the sphBC genes to metabolize sphingosine, reducing its inhibitory effects on bacterial growth.

Microbiology · Jan 10, 2025Peer-reviewedMicrobiology