Matthew J. Wargo

This study identifies genes affecting PlcH production in Pseudomonas aeruginosa using a genome-wide transposon screen and confirms their roles through deletion mutants.

This study shows that mesenchymal stromal cell-derived extracellular particles reduce Pseudomonas aeruginosa lung infection and inflammation in a cystic fibrosis mouse model.

This study identifies EPS-I as a key factor enabling Ralstonia solanacearum biofilms to exhibit viscoelastic fluid behavior, enhancing pathogen dissemination in planta.

This paper shows that sphingosine enhances the effectiveness of polymyxin antibiotics against Gram-negative bacteria like Pseudomonas aeruginosa and Klebsiella pneumoniae by reducing their minimum inhibitory concentrations.

This paper shows that let-7b-5p-loaded MSC EVs block antibiotic-resistant P. aeruginosa biofilm formation and reduce inflammation in CF bronchial epithelial cells.

This paper shows that PlcH and C. perfringens alpha toxin hydrolyze sphingosylphosphorylcholine (SPC), a signaling sphingolipid, which may be a common target for phosphocholine-specific phospholipases during infection.

This study shows that Pseudomonas aeruginosa uses the sphBC genes to metabolize sphingosine, reducing its inhibitory effects on bacterial growth.