Presymptomatic neuroanatomical and cognitive biomarkers of alpha-synuclein propagation in a mouse model of synucleinopathy
Stéphanie Tullo, Aline Silva de Miranda, Esther del Cid‐Pellitero, Mei Peng Lim, Daniel Gallino, Anoosha Attaran, Raihaan Patel, Vladislav Novikov, Megan Park, Flávio H. Beraldo, Wen Luo, Irina Shlaifer, Thomas M. Durcan, Timothy J. Bussey, Lisa M. Saksida, , M. Mallar Chakravarty
This study identifies neuroanatomical and cognitive biomarkers of alpha-synuclein propagation in a mouse model, showing early cognitive deficits and brain atrophy linked to prion-like spread of misfolded alpha-synuclein.
bioRxiv · Oct 12, 2022 · PreprintNeuroscience