NeuroscienceJCI InsightPeer-reviewed
Benefits of global mutant huntingtin lowering diminish over time in a Huntington's disease mouse model
Deanna M. Marchionini, Jeh-Ping Liu, Alberto Ambesi‐Impiombato…·Scott O. Zeitlin
This study shows that moderate global lowering of mutant Huntingtin in a HD mouse model delays some deficits but benefits diminish over time, suggesting long-term mHtt lowering may be needed for sustained benefit.
22 citations