Author

Scott O. Zeitlin

University of VirginiaORCID 0000-0003-1054-3343Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Organism:human· 1

Frequent Co-Authors

David HowlandiD· 2 shared Deanna M. MarchioniniiD· 2 shared Alberto Ambesi‐ImpiombatoiD· 1 shared Brenda Lager· 1 shared C. Frank BennettiD· 1 shared Cassandra A. McHughiD· 1 shared Christopher HartliD· 1 shared Daniela BrunneriD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

David HowlandORCID

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2 papers

Recent·Most cited

NeuroscienceJCI InsightPeer-reviewedOct 23, 2022

Benefits of global mutant huntingtin lowering diminish over time in a Huntington's disease mouse model

Deanna M. Marchionini, Jeh-Ping Liu, Alberto Ambesi‐Impiombato…·Scott O. Zeitlin

This study shows that moderate global lowering of mutant Huntingtin in a HD mouse model delays some deficits but benefits diminish over time, suggesting long-term mHtt lowering may be needed for sustained benefit.

22 citations

mouseexperimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintJul 23, 2020

Huntingtin lowering reduces somatic instability at CAG-expanded loci

Sydney R. Coffey, Marissa A Andrew, Heather Ging…·Jeffrey B. Carroll

This study shows that reducing huntingtin protein levels decreases somatic instability in CAG-expanded loci in both mouse models and human neurons.

8 citations

𝕏 PostBluesky