Finn Peters

This study demonstrates that Zinc Finger Repressors (ZFRs) reduce prion protein (PrP) expression in nonhuman primates and extend survival in prion disease mice.

This study shows that moderate global lowering of mutant Huntingtin in a HD mouse model delays some deficits but benefits diminish over time, suggesting long-term mHtt lowering may be needed for sustained benefit.

This study shows that chronic PPARγ agonist treatment increases amyloid-beta fibrillarity but improves cognition and synaptic density in mouse models.

This paper develops a PET radioligand to visualize mutant huntingtin levels in the brain and assess therapeutic interventions in Huntington's disease.

This study shows that microbiota-derived short chain fatty acids (SCFA) increase Aβ plaque deposition in Alzheimer's disease by promoting microglial activation and ApoE upregulation.

This study shows that pre-therapeutic microglia activation and sex predict the response to chronic immunomodulation in AD mouse models using TSPO-PET.