Christopher Hartl

This study shows that moderate global lowering of mutant Huntingtin in a HD mouse model delays some deficits but benefits diminish over time, suggesting long-term mHtt lowering may be needed for sustained benefit.

The paper compares co-expression network conservation across human, mouse, and non-human primate brain data, identifying divergence patterns and disease-related genes.

The paper identifies widespread transcriptomic dysregulation across multiple cortical regions in ASD, showing regional variation and genetic enrichment in synaptic and protein folding genes.

The paper identifies brain-wide and region-specific gene co-expression modules using RNA-seq data and links them to disease risk variants and biological processes.

The paper characterizes genetic control of gene expression and splicing in developing human brains using eQTL and sQTL analysis, identifying novel regulatory regions and links to neuropsychiatric disorders.

This study uses whole-genome sequencing in multiplex families to identify novel inherited and de novo genetic risk factors for autism, revealing 16 new ASD-risk genes and supporting 69 total genes.