Isoform switch of CD47 provokes macrophage-mediated pyroptosis in ovarian cancer
Zixiang Wang, Lei Yang, Siyuan Yang, Gaoyuan Li, Meining Xu, Beihua Kong, Changshun Shao, Zhaojian Liu
This study shows that switching CD47 isoforms from full-length to truncated in ovarian cancer cells triggers macrophage-mediated pyroptosis and reduces tumor growth.
bioRxiv · Apr 17, 2025 · PreprintCancer Biology