G51D mutation of the endogenous rat Snca gene disrupts synaptic localisation of α-synuclein priming for Lewy-like pathology
Stephen West, Ammar Natalwala, Karamjit Singh Dolt, Douglas J. Lamont, Melanie McMillan, Kelvin C. Luk, Tomoji Mashimo, Tilo Kunath
This study introduces a G51D mutation in the rat Snca gene, leading to synaptic mislocalization of α-synuclein and increased susceptibility to Lewy-like pathology.
bioRxiv · Oct 27, 2023 · PreprintNeuroscience