Tilo Kunath

The paper benchmarks dopaminergic stem cell models and cell therapy candidates using a human brain atlas to identify off-target populations and lineage plasticity.

This study compares immune responses to dopaminergic progenitor transplants in immunodeficient and cyclosporine-immunosuppressed rats, finding that hydrogel benefits depend on immunosuppression adequacy.

This study develops a method to detect and quantify extracellular vesicles using fluorescent antibodies and single-molecule confocal microscopy, achieving femtomolar sensitivity without purification.

FAST-STEM accelerates human pluripotent stem cell engineering by enabling rapid transgene integration and differentiation into multiple cell types.

This study introduces a G51D mutation in the rat Snca gene, leading to synaptic mislocalization of α-synuclein and increased susceptibility to Lewy-like pathology.

This paper introduces a method to specifically detect disease-associated protein aggregates using two-color coincidence single-molecule pull-down, demonstrating its effectiveness with alpha-synuclein in human biofluids.

This study uses 18F-DOPA PET imaging to identify a dopaminergic deficit in a rat model with a G51D α-synuclein mutation, showing reduced dopamine turnover and striatal asymmetry in aged animals.

This study uses hiPSCs with SNCA mutations to identify early molecular events in synucleinopathy, showing protein aggregation precedes functional impairments in midbrain dopaminergic neurons.

The paper tracks α-synuclein conformational changes in neurons and shows mitochondrial involvement in oligomerization and toxicity.

This study uses midbrain organoids from SNCA triplication patients to model synucleinopathy features, showing increased alpha-synuclein expression and aggregation linked to dopaminergic neuron loss.

This study shows alpha-synuclein is required for interferon-stimulated gene expression in neurons during RNA virus infection and links it to phosphorylated S129-asyn pathology.

Metabolomics identifies volatile odorous compounds from patient sebum that associate with the smell of Parkinsons.