Periweaning diet-induced activation of an IFNγ-mediated regulatory circuit promotes the homeostasis of cytotoxic CD8+ T Cells
Doğuş Altunöz, Ramin Shakiba, Kaushikk Ravi Rengarajan, Hamsa Narasimhan, Nikos E. Papaioannou, Sadiq Nasrah, Jessica Vetters, Maria L. Richter, María Parra Reyes, Nadine Nuschele, Denise Messerer, Sabine Schwamberger, Andreas Goschin, Dimitrios Starfas, Melanie Schmid, , Barbara U. Schraml
The paper shows that periweaning diet activates an IFNγ-mediated circuit in cDC1 that promotes effector memory CD8 T cell homeostasis through immunogenic maturation.
bioRxiv · Mar 31, 2026 · PreprintImmunology