Friedrich Frischknecht

This study uses imaging to show how TRAP and CSP dynamics drive adhesion and trail formation in malaria sporozoites, revealing a link between adhesion and trail formation.

This study identifies Alp1 as essential for Plasmodium ookinete motility and infection establishment in mosquitoes by regulating actin filament turnover.

The paper identifies insecticides that affect both mosquito vectors and malaria parasites, demonstrating a scalable method to find compounds that kill mosquitoes and suppress parasite transmission.

iSBEM automates ROI targeting in SBF-SEM using XRM maps, improving acquisition throughput while maintaining targeting precision in biological specimens.

This study identifies distinct roles of TRAP and TRP1 adhesins in Plasmodium sporozoite motility and invasion, showing differential signaling requirements for gliding and transmission.

This study investigates the role of Plasmodium Alp3 and Alp5a in mosquito infection, finding that Alp5a is critical for sporozoite formation and oocyst development, while Alp3 is essential for ookinete penetration.

This study uses high-resolution proteomics to show that Plasmodium infection disrupts mosquito salivary glands, causing exchange of proteins between hemolymph and saliva.

The paper investigates how B cells targeting Plasmodium parasites capture spatially linked antigens to receive T cell help, showing that B cells can obtain help from T cells specific to surface antigens, not just the same protein.

This study uses traction force microscopy to show that TLP modulates force generation in malaria sporozoites during gliding motility.

This study investigates microtubule dynamics during Plasmodium liver stage development and identifies C-terminal tubulin modifications as critical for parasite growth and transmission.

This paper identifies a novel microtubule-associated protein, SPM3, essential for malaria parasite transmission by affecting gametocyte morphology and sporozoite motility.

SPOT is a web tool for rapid comparative transcriptome analysis, enabling differential expression and gene ranking based on user-defined profiles.

This study shows that phosphorylation of myosin A at serine 19 is essential for Plasmodium sporozoite motility and efficient mosquito transmission.

This study shows that the I-domain of TRAP in Plasmodium parasites mediates adhesion and that its cationic charge and polyspecificity are critical for infectivity.