Maria Lucia Richter

Antagonizing niche signals regulate the emergence of postnatal neural stem cells and allow enlargement of their pool

The paper identifies ECM remodeling differences between slowly and rapidly dividing RGCs that regulate aNSC emergence and pool size through in vivo perturbation and single-cell RNA-sequencing.

Cilia beating of ependymal cells regulates adult neural stem cell quiescence via mechanical forces mediated by PKD1/2-TRPM3

The paper shows that ependymal cell cilia beating regulates neural stem cell quiescence through mechanical forces involving PKD1/2 and TRPM3.

Comprehensive single cell profiling of ageing glial cells reveals impaired Wnt signalling and Jun transcription factors regulating cortical astrocytes

The paper identifies age-related changes in cortical astrocytes, including impaired Wnt signaling and Jun transcription factors, using single-cell RNA-seq and multiome analysis in mice.

Periweaning diet-induced activation of an IFNγ-mediated regulatory circuit promotes the homeostasis of cytotoxic CD8+ T Cells

The paper shows that periweaning diet activates an IFNγ-mediated circuit in cDC1 that promotes effector memory CD8 T cell homeostasis through immunogenic maturation.

Benchmarking scRNA-seq copy number variation callers

This study benchmarks six scRNA-seq CNV callers using 15 datasets, finding that reference choice and allelic information impact performance, with some methods being more robust but computationally intensive.

Cross-species analyses reveal RORγt-expressing dendritic cells are a lineage of antigen presenting cells conserved across tissues

The paper identifies RORγt-expressing dendritic cells as a distinct APC lineage conserved across tissues and species, with functions beyond promoting tolerance.

TGIF2 is a major regulator of neural stem cell fate and neurogenic priming

The paper identifies TGIF2 as a key regulator of neural stem cell fate and neurogenic priming through transcriptomic and chromatin analysis in mouse brain development.

epiScanpy: integrated single-cell epigenomic analysis

epiScanpy enables analysis of single-cell DNA methylation and ATAC-seq data using scanpy workflows, showing epigenetic markers enrich cell type labels.

Single-nucleus RNA-seq2 reveals a functional crosstalk between liver zonation and ploidy

The paper develops a single-nucleus RNA-seq2 method to study ploidy and spatial zonation in hepatocytes, finding gene expression in tetraploid cells depends on their hepatic lobe position.