Strong inhibition of insulin/IGF-1 signaling in early-mid adulthood compresses morbidity, but in later life accelerates aging
Bruce Zhang, Kuei Ching Hsiung, Reva Biju, Marybelle Cameron-Pack, Xiaoya Wei, Hannah Chapman, Melisa Kelaj, Aihan Zhang, Chiminh Nguyen Hong, Collin Y. Ewald, David Gems
This study shows that reducing insulin/IGF-1 signaling in early adulthood extends healthspan and lifespan, but in later life, it accelerates aging and reduces lifespan.
bioRxiv · Apr 16, 2026 · PreprintGenetics