GeneticsbioRxivPreprint
Strong inhibition of insulin/IGF-1 signaling in early-mid adulthood compresses morbidity, but in later life accelerates aging
Bruce Zhang, Kuei Ching Hsiung, Reva Biju…·David Gems
This study shows that reducing insulin/IGF-1 signaling in early adulthood extends healthspan and lifespan, but in later life, it accelerates aging and reduces lifespan.
DOI 10.64898/2026.04.15.718682