Enhancer-directed gene delivery for digit regeneration based on conserved epidermal factors
David A. Brown, Katja K. Koll, Erin Brush, Grant R. Darner, Timothy Curtis, Thomas Dvergsten, Melissa A. Tran, Colleen Milligan, David W. Wolfson, Trevor J. Gonzalez, Sydney E. Jeffs, Alyssa Ehrhardt, Rochelle Bitolas, Madeleine B. Landau, Kendall Reitz, , Kenneth D. Poss
This paper develops a gene therapy approach for digit regeneration using enhancer-directed delivery of FGF8 to restore impaired regeneration in SP transcription factor knockout mice.
Proceedings of the National Academy of Sciences · Apr 14, 2026Peer-reviewedGenetics