GeneticsCell Host & MicrobePeer-reviewed
Recurrent loss-of-function mutations reveal costs to OAS1 antiviral activity in primates
Clayton M. Carey, Apurva A. Govande, Juliane M. Cooper…·Nels C. Elde
The paper identifies recurrent loss-of-function mutations in OAS1 across primates, showing that the cytotoxic effects of OAS1 activation can outweigh its antiviral benefits, leading to reduced catalytic activity.
44 citations