Nels C. Elde

The paper shows that ciliates enhance zebrafish virus transmission by concentrating viruses, but not all viruses are transmitted, suggesting selectivity.

This study uses comparative genomics and evolutionary analysis to uncover hidden signaling interactions and functional roles of IL-17 cytokines beyond immunity.

This study identifies multiple genetic routes to thermotolerance in Cryptococcus neoformans through experimental evolution under increasing temperatures.

The paper identifies a reptilian TRIM-family E3 ligase that strongly restricts dengue virus replication and highlights immune diversity in reptile genomes.

The paper investigates the evolutionary origins of viral phosphodiesterases (PDEs) that inhibit the OAS-RNase L antiviral pathway, identifying multiple horizontal transfer events and structural divergence patterns.

The paper identifies a conserved mitochondrial stress response network (MISTR) by analyzing evolutionary conflict signatures across species, revealing its role in stress response and pathogen resistance.

The paper identifies recurrent loss-of-function mutations in OAS1 across primates, showing that the cytotoxic effects of OAS1 activation can outweigh its antiviral benefits, leading to reduced catalytic activity.

This study identifies rapid evolution of primate type 2 immune response factors, including IL13 and eosinophil granule proteins, linked to asthma susceptibility in humans.

This study shows how vaccinia virus adapts to host immune defenses through point mutations in RNA polymerase and gene copy number variation, accelerating the spread of beneficial mutations.

This study investigates the evolutionary role of lactoferrin's antimicrobial functions in primate and human genetic conflicts, showing evidence of positive selection and links to modern genetic variation.