Author

Melissa van de Wal

Radboud University Medical Center

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Neuroscience· 1

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Approach:experimental assay· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

Chao Ciu-Gwok GuoiD· 1 shared Joanes GrandjeaniD· 1 shared Judith Regina HombergiD· 1 shared Lianne Remie· 1 shared Noortje M. P. OverwateriD· 1 shared Samir el Bouazzati· 1 shared Werner Koopman· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Chao Ciu-Gwok GuoORCID

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1 paper

Recent·Most cited

Resting state fMRI detects pathological functional brain connectivity in the Ndufs4 knockout mouse model of Leigh syndrome during the pre-symptomatic stage of the disease

Chao Ciu-Gwok Guo, Melissa van de Wal, Samir el Bouazzati, Noortje M. P. Overwater, Lianne Remie, Werner Koopman, Joanes Grandjean, Judith Regina Homberg

The paper uses rs-fMRI to detect altered functional connectivity in Ndufs4 knockout mice during the pre-symptomatic stage of Leigh syndrome, finding increased connectivity in multiple brain regions and no effect of KH176 treatment.

bioRxiv · Oct 24, 2026 · PreprintNeuroscience