Senescent cells induce vascular MHC II to recruit CD4+ T cells and drive inflammation in aging adipose tissue
Qijing Xie, Tzu‐Hua Lin, SoRi Jang, Calvin H. Jan, Amirali Selahi, Kendra Dee Nyberg, Agnieszka A. Wendorff, Kayley Hake, Austin E. Y. T. Lefebvre, Meng Jin, Andrea Di Francesco, Maria V. Pokrovskii, Helen Tauc-Adrian, Cynthia J. Kenyon
This study identifies senescent cells as drivers of age-related inflammation in adipose tissue by inducing vascular MHC II and recruiting CD4+ T cells through an IFN-gamma feedback loop.
bioRxiv · May 16, 2026 · PreprintImmunology