Austin E.Y.T. Lefebvre

This study identifies senescent cells as drivers of age-related inflammation in adipose tissue by inducing vascular MHC II and recruiting CD4+ T cells through an IFN-gamma feedback loop.

The paper quantifies age-related morphological changes in human skin using imageomics and shows xenografting induces rejuvenation-like changes regardless of host age.

The paper uses genetic correlation analysis in DO mice to identify QTL and candidate genes linked to age-related pathologies.

This study identifies a biophysical mechanism for mitochondrial pearling, showing it occurs spontaneously in various cell types and is driven by internal pressure or external tension.

This paper uses FLIM to study nanoplastic interactions and effects in intestinal organoids, finding species-specific uptake and disruptions in mitochondrial function and inflammation.

This paper introduces an automated pipeline to quantify elastic fiber architecture in mouse aorta histology, enabling objective, high-throughput analysis of vascular structure.