Cynthia J. Kenyon

Senescent cells induce vascular MHC II to recruit CD4+ T cells and drive inflammation in aging adipose tissue

This study identifies senescent cells as drivers of age-related inflammation in adipose tissue by inducing vascular MHC II and recruiting CD4+ T cells through an IFN-gamma feedback loop.

Imageomics defines granular morphological changes of human skin with age and reveals a rejuvenating effect of xenografting

The paper quantifies age-related morphological changes in human skin using imageomics and shows xenografting induces rejuvenation-like changes regardless of host age.

A mathematical model that predicts human biological age from physiological traits identifies environmental and genetic factors that influence aging

The paper develops a model to predict biological age from physiological traits, identifies factors influencing aging, and links {Delta}Age to mortality risk.

A FMRF-amide peptide that regulates cell non-autonomous protein homeostasis in C. elegans.

This study identifies FLP-17, a neuropeptide that mediates cell non-autonomous UPRER activation in C. elegans, protecting against ER stress and protein aggregation.

The complete cell atlas of an aging multicellular organism

This paper creates a single-cell atlas of aging in C. elegans, revealing cell-type specific aging patterns and identifying transcription factors that regulate aging rates.

Partial reprogramming restores youthful gene expression through transient suppression of cell identity

This study investigates how transient reprogramming affects somatic cell identity and aging in mice, finding that it can restore youthful gene expression but also suppress identity programs.

Revisiting the Hayflick Limit: Insights from an Integrated Analysis of Changing Transcripts, Proteins, Metabolites and Chromatin

The paper analyzes replicative senescence in WI-38 cells using multi-omics data, finding early senescence markers, myofibroblast-like transitions, and YAP1/TEAD1 regulation.

Split-wrmScarlet and split-sfGFP: Tools for faster, easier fluorescent labeling of endogenous proteins in Caenorhabditis elegans

The paper introduces split-wrmScarlet and split-sfGFP tools for faster fluorescent labeling of endogenous C. elegans proteins using CRISPR.

Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules that Affect Aging Pathways and Extend C. elegans Lifespan

The paper screens 100,000 small molecules in human fibroblasts to find those increasing oxidative stress resistance and extending C. elegans lifespan.

A resource for analyzing C. elegans’ gene expression data using transcriptional gene modules and module-weighted annotations

The paper defines 209 gene modules for C. elegans using DEXICA and shows they improve functional interpretation of gene expression data.

Rescue of a developmental arrest caused by a C. elegans heat-shock transcription-factor mutation by loss of ribosomal S6-kinase activity

This study identifies that loss of rsks-1/S6-Kinase rescues developmental arrest in C. elegans hsf-1 mutants, revealing an unexplained regulatory link between heat-shock transcription factors and the TOR pathway during development.

Inferring Weighted Gene Annotations from Expression Dat

The paper develops a method to generate weighted gene annotations from Boolean annotations and gene expression data, showing improved resistance to gene-gene correlations and revealing biological insights.