Post-translational modifications orchestrate the intrinsic signaling bias of orphan receptor GPR52
Bingjie Zhang, Wei Ge, Mengna Ma, Shanshan Li, Jie Yu, Guang Yang, Huilan Wang, Jingwen Li, Qingrun Li, Rong Zeng, Boxun Lu, Wenqing Shui
This study identifies how N-glycosylation and phosphorylation in specific motifs of GPR52 differentially regulate its signaling bias and cellular function.
Nature Chemical Biology · Mar 14, 2025Peer-reviewedCell Biology