Dual histone methylation reader ZCWPW2 links histone methylation to initiation of meiotic recombination
Shenli Yuan, Shiyu Wang, Ziyou Bao, Ziqi Wang, Kang Shangguan, Yelian Yan, Yajun Shi, Xu Feng, Chengqi Huang, Mengrui Fang, Hongyun Zhao, Shigang Zhao, Liu H, Z Chen, Tao Huang
This study identifies ZCWPW2 as a dual histone methylation reader that links H3K4me3 and H3K36me3 to meiotic DSB formation by interacting with key recombination proteins.
bioRxiv · May 26, 2026 · PreprintCell Biology