Author

Mengxi Zhang

Rice University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Han XiaoiD· 2 shared Peter Guy WolynesiD· 2 shared Shikai JiniD· 2 shared Yuda CheniD· 2 shared Anna ChungiD· 1 shared Kuan‐Lin WuiD· 1 shared Shichao WangiD· 1 shared Shudan YangiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

Han XiaoORCID

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2 papers

Recent·Most cited

Real-Time Visualization of Protein Microenvironment Changes with High Spatial Resolution in Live Cells via Site-Specific Incorporation of Rotor-Based Fluorescent Noncanonical Amino Acids

Shudan Yang, Shikai Jin, Mengxi Zhang, Yuda Chen, Yiming Guo, Yu Hu, Peter Guy Wolynes, Han Xiao

This study develops a method to visualize protein microenvironment changes in live cells using rotor-based fluorescent noncanonical amino acids incorporated at specific sites.

Nature Chemical Biology · Sep 11, 2025Peer-reviewedBiochemistry

Unleashing the Potential of Noncanonical Amino Acid Biosynthesis for Creation of Cells with Site-Specific Tyrosine Sulfation

Yuda Chen, Shikai Jin, Mengxi Zhang, Yu Hu, Kuan‐Lin Wu, Anna Chung, Shichao Wang, Zeru Tian, Yixian Wang, Peter Guy Wolynes, Han Xiao

This paper reports the creation of autonomous cells capable of biosynthesizing and genetically encoding sulfotyrosine, enabling site-specific protein sulfation with higher efficiency than exogenous feeding.

Nature Communications · Sep 16, 2022Peer-reviewedSynthetic Biology