Shikai Jin

Real-Time Visualization of Protein Microenvironment Changes with High Spatial Resolution in Live Cells via Site-Specific Incorporation of Rotor-Based Fluorescent Noncanonical Amino Acids

This study develops a method to visualize protein microenvironment changes in live cells using rotor-based fluorescent noncanonical amino acids incorporated at specific sites.

DNA polymerase actively and sequentially displaces single-stranded DNA-binding proteins

This study investigates how DNA polymerase displaces SSBs during replication, showing sequential displacement and the role of SSB saturation in replication efficiency.

Unleashing the Potential of Noncanonical Amino Acid Biosynthesis for Creation of Cells with Site-Specific Tyrosine Sulfation

This paper reports the creation of autonomous cells capable of biosynthesizing and genetically encoding sulfotyrosine, enabling site-specific protein sulfation with higher efficiency than exogenous feeding.

OpenAWSEM with Open3SPN2: a fast, flexible, and accessible framework for large-scale coarse-grained biomolecular simulations

This paper introduces OpenAWSEM and Open3SPN2, GPU-accelerated coarse-grained simulation tools for proteins and DNA, enabling faster and more flexible modeling of biomolecular systems.