Yuda Chen

This study identifies features contributing to catalytic efficiency in a de novo enzyme through computational design and directed evolution, showing how stability and dynamics interplay in enzyme optimization.

This study develops a method to visualize protein microenvironment changes in live cells using rotor-based fluorescent noncanonical amino acids incorporated at specific sites.

This paper designs de novo Rhodamine Binder (Rhobin) tags with high brightness, stability, and applicability in live-cell imaging and extreme conditions.

This paper reports the creation of autonomous cells capable of biosynthesizing and genetically encoding sulfotyrosine, enabling site-specific protein sulfation with higher efficiency than exogenous feeding.