Occidiofungin, an actin binding antifungal with in vivo efficacy in a vulvovaginal candidiasis infection
Akshaya Ravichandran, Mengxin Geng, Kenneth G. Hull, Daniel Romo, Shi-En Lu, Aaron Albee, Christopher Nutter, Donna M. Gordon, Mahmoud A. Ghannoum, Steve W. Lockless, Leif Smith
This paper identifies occidiofungin, a novel antifungal compound produced by Burkholderia contaminans, which targets actin and shows efficacy in treating vulvovaginal candidiasis in mice with reduced host toxicity.
bioRxiv · Jul 13, 2018 · PreprintMicrobiology