Daniel Romo

This paper shows that combining HDAC and eIF4A inhibitors effectively treats pancreatic cancer by inducing epigenetic reprogramming and metabolic stress in preclinical models.

This study identifies ophiobolin A's mechanism of action against EMT-positive breast cancer cells, showing mitochondrial and metabolic disruption with antioxidant countermechanisms.

This study shows that ophiobolin A induces PANoptosis in breast cancer cells through RIPK1-dependent mechanisms, leading to lytic and pro-inflammatory cell death.

This paper identifies pateamine A as a small-molecule compound that selectively represses mRNA translation by anchoring eIF4A and DDX3 to GNG motifs.

This paper identifies occidiofungin, a novel antifungal compound produced by Burkholderia contaminans, which targets actin and shows efficacy in treating vulvovaginal candidiasis in mice with reduced host toxicity.