Closed-loop sonothermogenetic control of CAR T cells for metronomic brain cancer therapy
Ali H. Zamat, Chulyong Kim, Shwetha Sridhar, Sydney Fábrega, Riya Sen, Noah Campbell, S. Abbey Oliver, Zizhen Zha, Chloé A. Thiveaud, Elif Kulaksizoglu, Meredith Brienen, Hideho Okada, Graeme F. Woodworth, Costas Arvanitis, Gabriel A. Kwong
This study demonstrates closed-loop sonothermogenetic control of CAR T cells to achieve metronomic activation in brain tumors without harming healthy tissue.
bioRxiv · Apr 23, 2025 · PreprintBioengineering