Structural polymorphism of amyloid fibrils in cardiac ATTR amyloidosis revealed by cryo-electron microscopy
Binh An Nguyen, Shumaila Afrin, Virender Pratap Singh, Yasmin Ahmed, Rose Pedretti, María del Carmen Fernández‐Ramírez, Merrill Douglas Benson, Michael R. Sawaya, Preeti Singh, Qin Cao, David R. Boyer, Alexander Pope, Paweł M. Wydorski, Siddharth Kumar, Farzeen Chhapra, , Lorena Saelices
The paper uses cryo-electron microscopy to show that cardiac ATTR amyloid fibrils are structurally polymorphic, independent of genotype and phenotype, challenging the one-fibril-fold-per-disease paradigm.
bioRxiv · Jun 21, 2022 · PreprintMolecular Biology