Author

Paweł M. Wydorski

The University of Texas Southwestern Medical CenterORCID 0000-0002-6983-421XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Alexander Pope· 1 shared Binh An NguyeniD· 1 shared David R. BoyeriD· 1 shared David S EisenbergiD· 1 shared Farzeen Chhapra· 1 shared Jaime Vaquer‐AliceaiD· 1 shared Lorena SaelicesiD· 1 shared Łukasz A. JoachimiakiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperMolecular Biology

Alexander Pope

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2 papers

Recent·Most cited

DnaJB1 chaperone inhibits tau aggregation by recognizing its N-terminus

Paweł M. Wydorski, Paulina Macierzyńska, Sofia Bali, Jaime Vaquer‐Alicea, Łukasz A. Joachimiak

This study shows DnaJB1 inhibits tau aggregation by binding its N-terminus in vitro and in cellular models, with interactions enhanced by polyanionic factors.

bioRxiv · Oct 2, 2025 · PreprintBiochemistry

Structural polymorphism of amyloid fibrils in cardiac ATTR amyloidosis revealed by cryo-electron microscopy

Binh An Nguyen, Shumaila Afrin, Virender Pratap Singh, Yasmin Ahmed, Rose Pedretti, María del Carmen Fernández‐Ramírez, Merrill Douglas Benson, Michael R. Sawaya, Preeti Singh, Qin Cao, David R. Boyer, Alexander Pope, Paweł M. Wydorski, Siddharth Kumar, Farzeen Chhapra, , Lorena Saelices

The paper uses cryo-electron microscopy to show that cardiac ATTR amyloid fibrils are structurally polymorphic, independent of genotype and phenotype, challenging the one-fibril-fold-per-disease paradigm.

bioRxiv · Jun 21, 2022 · PreprintMolecular Biology