Hydroperoxy-lipids Are Essential Yet Insufficient For Execution Of Ferroptosis
Светлана Николаевна Самович, Alexandr A. Kapralov, Louis J. Sparvero, Brian A. Kleiboeker, Mert Akdogan, Andrew A. Amoscato, Yulia Y. Tyurina, Sally E. Wenzel, Dmitry I. Gabrilovich, Yuri L. Bunimovich, Brent R. Stockwell, Valerian E. Kagan, Hülya Bayır
The paper shows that hydroperoxy-phospholipids are necessary but insufficient for ferroptosis, requiring additional Fe-catalyzed processes and agents to complete the death program.
bioRxiv · Sep 18, 2026 · PreprintBiochemistry