Hülya Bayır

The paper shows that hydroperoxy-phospholipids are necessary but insufficient for ferroptosis, requiring additional Fe-catalyzed processes and agents to complete the death program.

This study finds that many critically ill children receive medications with established pharmacogenomic guidelines, but exome sequencing identifies actionable PGx variants that could improve treatment.

This study shows targeting the LxCxE cleft pocket of Rb in M2 macrophages inhibits ovarian cancer progression by reducing immunosuppressive TAMs and enhancing T cell infiltration.

This paper characterizes a mouse model of Snyder-Robinson Syndrome with a missense mutation in the Sms gene, revealing behavioral, neuroanatomical, and metabolic defects.

This study identifies conjugated linolenic acids as ferroptosis inducers in triple-negative breast cancer and shows their anti-tumor effects in a xenograft model.

This paper builds a computational model to study how cells decide between autophagy and apoptosis under stress, revealing that cytoplasmic Ca2+ acts as a rheostat regulated by G-protein signaling and AMPK.