Performance of Core Genome Multilocus Sequence Typing Compared to Capillary-Electrophoresis PCR Ribotyping and SNP Analysis of Clostridioides difficile
Amoe Baktash, Jeroen Corver, Céline Harmanus, Wiep Klaas Smits, Warren N. Fawley, MH Wilcox, Nitin Kumar, David W. Eyre, A. Indra, Alexander Mellmann, Ed J. Kuijper
The paper compares core genome MLST (cgMLST) with CE-PCR ribotyping and SNP analysis for C. difficile typing, finding cgMLST offers better discrimination but may require adjusted thresholds for outbreak detection.
bioRxiv · Aug 10, 2021 · PreprintMolecular Biology